Valpha® Kapsule Virus Removal Filter

Tofflon Saipu Valpha® family of virus removal filters are designed to efficiently remove virus particles from biological products ( blood products, antibody drugs, etc. ). The Valpha® family of virus removal filters are validated to provide you reliable virus retention even at higher levels of virus challenge. Valpha® is your trusted virus security partner.

Valpha® advantages

• Reliable virus removal ability
• Mice Minute Virus(MMV)reduction rate LRV≥4
• Antibody protein (150kD) recover rate≥99% High efficient virus filtering unit
• Water based integrity testing, easy to test Single-use design, no cleaning validation required
• Sterility
• High pressure resistance
• High capability
• High flux, shorten the lot filtration time
• No additional filtration systems such as stainless steel clamps and accessories are required

Key to virus security

Valpha® virus removal filters use membrane filtration technology to remove virus particles based on size exclusion. It uses an innovative high-performance polymer membrane to trap the virus on the membrane surface and in the membrane pores. Key performance parameters are usually logarithmic removal rate (LRV), flux, and load. These parameters are infiuenced by many interacting factors, such as virus loading, protein concentration, impurity concentration, pressure, process flow rate, ion strength, and process interruption. Therefore, it is very important to select and validate the appropriate virus removal filter under the established process conditions.

Valpha® family virus removal filters provide you two choices of membrane: Valpha RC(Regenerated Cellulose) and Valpha PES(Modified PolyEtherSulfone).

Valpha® RC uses regenerated cellulose membrane. Cellulose is a high hydrophilic material and is widely used as a basic polymer in the preparation of filtration membranes. The natural hydrophilic properties of cellulose maximize protein recovery by reducing protein adsorption. In addition, cellulose membrane can maintain high LRV value and filtration flow rate in long time filtration. Moreover, it has broad applicability and is suitable for virus removal process of multiple biological products.

Valpha® PES uses modified polyethersulfone material, and its unique asymmetric structure provides more possibilities for high process flux. At the same time, Saipu unique modification and membrane preparation process provides Valpha PES membrane very low protein adsorption and high flow rate. It really achieves the target of high flux, high load and high

Requirements for virus clearance

• Effective retention
• High yield
• Easy to use
• Shorter filtration time
• High capacity
• Can be validated
• Process robust

Unique virus removal membrane technology

Valpha® RC

• High retention

• High Capacity

• Stable flux, suitable for polyclonal antibody, plasma products,

  biochemical extracts and other complex feed liquid

Valpha® RC HP

•  High retention

• High capacity

•  Designed for high-concentration plasma products

Valpha® PES

• High retention

• High capacity

• High flux, improve filtration efficiency and reduce process time